Cross-clade inhibition of HIV-1 replication and cytopathology by using RNase P-associated external guide sequences.

@article{Kraus2002CrosscladeIO,
  title={Cross-clade inhibition of HIV-1 replication and cytopathology by using RNase P-associated external guide sequences.},
  author={Gunter Kraus and Rebeca Geffin and Gina Spruill and Andrea K Young and Rachel Seivright and Diana Cardona and Jennifer K. Burzawa and H. James Hnatyszyn},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 6},
  pages={3406-11}
}
RNase P complexes have been proposed as a novel RNA-based gene interference strategy to inhibit gene expression in human malignancies and infectious diseases. This approach is based on the sequence-specific design of an external guide sequence (EGS) RNA molecule that can specifically hybridize to almost any complementary target mRNA and facilitate its cleavage by the RNase P enzyme component. We designed a truncated RNase P-associated EGS molecule to specifically recognize the U5 region of HIV… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Inhibition of gene expression by RNase P.

New biotechnology • 2010
View 5 Excerpts
Highly Influenced

Gene Therapy for HIV and Chronic Infections

Advances in Experimental Medicine and Biology • 2015

Similar Papers

Loading similar papers…