Cross-clade CD8 T-cell responses to HIV(IIIB) and Chinese B' and C/B' viruses in North American and Chinese HIV-seropositive donors.

@article{FranoisBongaron2004CrosscladeCT,
  title={Cross-clade CD8 T-cell responses to HIV(IIIB) and Chinese B' and C/B' viruses in North American and Chinese HIV-seropositive donors.},
  author={Vanessa François-Bongarçon and Yi Feng and Sang-Kyung Lee and Gang Chen and Premlata Shankar and Ying Liu and Xin Tao and Yongzhao Shao and Judy Lieberman},
  journal={Journal of acquired immune deficiency syndromes},
  year={2004},
  volume={37 4},
  pages={
          1435-44
        }
}
HIV variation presents an obstacle to a global AIDS vaccine. Viral diversity and host variations in MHC expression both affect vaccine responses. Whether CD8 T cells from HIV-infected donors in 1 part of the world cross-recognize isolates from other regions will provide guidance about whether country-specific vaccines are needed. We compared recognition of HIV(IIIB) and representative B' (Thai B) and recombinant C/B' virus strains endemic in China by CD8 T cells from 7 HIV-infected North… CONTINUE READING

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