Cross-bridge phosphorylation and regulation of latch state in smooth muscle.

  title={Cross-bridge phosphorylation and regulation of latch state in smooth muscle.},
  author={C M Hai and Richard A. Murphy},
  journal={The American journal of physiology},
  volume={254 1 Pt 1},
We have developed a minimum kinetic model for cross-bridge interactions with the thin filament in smooth muscle. The model hypothesizes two types of cross-bridge interactions: 1) cycling phosphorylated cross bridges and 2) noncycling dephosphorylated cross bridges ("latch bridges"). The major assumptions are that 1) Ca2+-dependent myosin phosphorylation is the only postulated regulatory mechanism, 2) each myosin head acts independently, and 3) latch bridges are formed by dephosphorylation of an… CONTINUE READING
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