Cross-bridge mechanisms of muscle weakness in multiple sclerosis.

  title={Cross-bridge mechanisms of muscle weakness in multiple sclerosis.},
  author={Dena P. Garner and Jeffrey J Widrick},
  journal={Muscle & nerve},
  volume={27 4},
Vastus lateralis muscle biopsies were obtained from six individuals with multiple sclerosis (MS) having an Expanded Disability Status Score of 4.75 +/- 0.28, and from six age- and gender-matched individuals without MS. Biopsies from the MS group showed fewer fibers (31 +/- 4 vs. 46 +/- 4%) containing the type IIa myosin heavy chain (MHC) isoform exclusively. However, the percentage of fibers coexpressing type IIa and IIx MHC increased in direct proportion with MS disability status. The average… CONTINUE READING

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