Cross-activating c-Met/β1 integrin complex drives metastasis and invasive resistance in cancer.

@article{Jahangiri2017CrossactivatingCI,
  title={Cross-activating c-Met/β1 integrin complex drives metastasis and invasive resistance in cancer.},
  author={Arman Jahangiri and Alan T Nguyen and Ankush Chandra and Maxim K Sidorov and Garima Yagnik and Jonathan Rick and Sung Won Han and William C. Chen and Patrick Flanigan and Dina Schneidman-Duhovny and Smita Mascharak and Michael D De Lay and Brandon S Imber and Catherine C. Park and Kunio Matsumoto and Kan V. Lu and Gabriele Bergers and Andrej Sali and William S. Weiss and Manish K Aghi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 41},
  pages={
          E8685-E8694
        }
}
The molecular underpinnings of invasion, a hallmark of cancer, have been defined in terms of individual mediators but crucial interactions between these mediators remain undefined. In xenograft models and patient specimens, we identified a c-Met/β1 integrin complex that formed during significant invasive oncologic processes: breast cancer metastases and… CONTINUE READING