Cross Talk between Insulin-Like Growth Factor I and AMP-Activated Protein Kinase as a Possible Cause of Vascular Dysfunction in the Amyloid Precursor Protein / Presenilin 2 Mouse Model of Alzheimer ’ s Disease

@inproceedings{LopezLopez2007CrossTB,
  title={Cross Talk between Insulin-Like Growth Factor I and AMP-Activated Protein Kinase as a Possible Cause of Vascular Dysfunction in the Amyloid Precursor Protein / Presenilin 2 Mouse Model of Alzheimer ’ s Disease},
  author={Cristina Lopez-Lopez and Marcelo de Oliveira Dietrich and Friedrich Metzger and Hansruedi Loetscher and Ign{\'a}cio Torres-Aleman},
  year={2007}
}
Cerebrovascular dysfunction appears to be involved in Alzheimer’s disease (AD). In double mutant amyloid precursor protein/presenilin 2 (APP/PS2) mice, a transgenic model of AD, vessel homeostasis is disturbed. These mice have elevated levels of vascular endothelial growth factor (VEGF) and increased brain endothelial cell division but abnormally low brain vessel density. Examination of the potential involvement of insulin-like growth factor I (IGF-I) in these alterations revealed that… CONTINUE READING
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