Cross-Talk Between Neurons and Astrocytes in Response to Bilirubin: Adverse Secondary Impacts

@article{Falco2013CrossTalkBN,
  title={Cross-Talk Between Neurons and Astrocytes in Response to Bilirubin: Adverse Secondary Impacts},
  author={Ana Sofia Falc{\~a}o and Rui F. M. Silva and Ana Rita Vaz and C{\'a}tia Gomes and Adelaide Fernandes and Andreia Pereira Barateiro and Claudio Tiribelli and Dora Brites},
  journal={Neurotoxicity Research},
  year={2013},
  volume={26},
  pages={1-15}
}
Previous studies using monotypic nerve cell cultures have shown that bilirubin-induced neurological dysfunction (BIND) involves apoptosis and necrosis-like cell death, following neuritic atrophy and astrocyte activation, and that glycoursodeoxycholic acid (GUDCA) has therapeutic efficacy against BIND. Cross-talk between neurons and astrocytes may protect or aggravate neurotoxicity by unconjugated bilirubin (UCB). In a previous work we have shown that bidirectional signaling during astrocyte… CONTINUE READING

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