Cross-Sectional Study of Lipids and Liver Enzymes Related to a Serum Biomarker of Exposure (ammonium perfluorooctanoate or APFO) as Part of a General Health Survey in a Cohort of Occupationally Exposed Workers

@article{Sakr2007CrossSectionalSO,
  title={Cross-Sectional Study of Lipids and Liver Enzymes Related to a Serum Biomarker of Exposure (ammonium perfluorooctanoate or APFO) as Part of a General Health Survey in a Cohort of Occupationally Exposed Workers},
  author={Carine J Sakr and Kim H. Kreckmann and John W Green and Peter J. Gillies and Julia Reynolds and Robin C. Leonard},
  journal={Journal of Occupational and Environmental Medicine},
  year={2007},
  volume={49},
  pages={1086-1096}
}
Objective: To examine the relationship between serum perfluorooctanoate (PFOA), a biomarker of ammonium perfluorooctanoate (APFO) exposure, and lipids and liver enzymes in a cross-sectional study among workers with potential occupational exposure to APFO. Methods: We conducted a cross-sectional study of 1025 active workers with potential exposure to APFO using linear regression to examine the relationship between PFOA and selected outcomes from a standard metabolic health screening survey… 

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References

SHOWING 1-10 OF 45 REFERENCES

Longitudinal Study of Serum Lipids and Liver Enzymes in Workers With Occupational Exposure to Ammonium Perfluorooctanoate

These medical surveillance data collected on workers for up to 25 years contributes useful information on the effects of ammonium perfluorooctanoate exposure on human liver and lipid chemistry.

Community Exposure to Perfluorooctanoate: Relationships Between Serum Levels and Certain Health Parameters

No toxicity from PFOA was demonstrated using the measured end points; other end points need to be addressed.

Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers

  • G. OlsenL. R. Zobel
  • Medicine
    International archives of occupational and environmental health
  • 2007
There was no evidence that employees’ serum PFOA concentrations were associated with total cholesterol or LDL, and several explanations are offered for the inconsistent triglyceride associations with PFO a including both methodological as well as biological possibilities.

Functional foods for coronary heart disease risk reduction: a meta-analysis using a multivariate approach.

PCA is useful for summarizing available scientific information in examinations of health claims for foods and supplements and showed that this behavior was independent of dose, number of patients per study, age, and body mass index but was associated with treatment length.

Serum perfluorooctanoic acid and hepatic enzymes, lipoproteins, and cholesterol: a study of occupationally exposed men.

The findings indicate that there is no significant clinical hepatic toxicity at the PFOA levels observed in this study and may modulate the previously described hepatic responses to obesity and xenobiotics.

An epidemiologic investigation of reproductive hormones in men with occupational exposure to perfluorooctanoic acid.

Results provide reasonable assurance that, in this production setting, there were no significant hormonal changes associated with PFOA at the serum levels measured, compared with those levels reported to cause effects in laboratory animal studies.

Community Exposure to Perfluorooctanoate: Relationships Between Serum Concentrations and Exposure Sources

Household water source was the primary determinant of serum (PFOA), and occupational exposure from production processes using PFOA and residential water had additive effects; no other occupations contributed.

Relationship between dietary intake, lipoproteins, and apolipoproteins in Taipei and Framingham.

The data indicate that the more favorable lipoprotein profiles observed in Taipei subjects may be partly due to differences in type of dietary fat consumption as well as in body mass index.

PLASMA CHOLECYSTOKININ AND HEPATIC ENZYMES, CHOLESTEROL AND LIPOPROTEINS IN AMMONIUM PERFLUOROOCTANOATE PRODUCTION WORKERS

There is no significant clinical hepatic toxicity associated with PFOA levels as measured in male workers involved in ammonium perfluorooctanoate production, and unlike a previously reported observation, P FOA did not appear to modulate hepatic responses to either obesity or alcohol consumption.

Lipoproteins, nutrition, and heart disease.

  • E. Schaefer
  • Medicine
    The American journal of clinical nutrition
  • 2002
The available data indicate that the recommendation to use fats, oils, and sugars sparingly for CHD prevention should be modified to a recommendation toUse animal, dairy, and hydrogenated fats; tropical oils; egg yolks; and sugar sparingly and to increase the use of vegetables, fruit, and whole grains.