Cross-Reactivity of Herpesvirus-Specific CD8 T Cell Lines Toward Allogeneic Class I MHC Molecules

@inproceedings{Morice2010CrossReactivityOH,
  title={Cross-Reactivity of Herpesvirus-Specific CD8 T Cell Lines Toward Allogeneic Class I MHC Molecules},
  author={Alexis Morice and B{\'e}atrice Charreau and B{\'e}rang{\`e}re Neveu and Sophie Brouard and Jean Paul Soulillou and Marc Bonneville and Elisabeth Houssaint and Nicolas Degauque},
  booktitle={PloS one},
  year={2010}
}
Although association between persistent viral infection and allograft rejection is well characterized, few examples of T-cell cross-reactivity between self-MHC/viral and allogeneic HLA molecules have been documented so far. We appraised in this study the alloreactivity of CD8 T cell lines specific for immunodominant epitopes from human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV). CD8 T cell lines were generated after sorting with immunomagnetic beads coated with either pp65(495-503)/A… CONTINUE READING
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