Cross-Protective Effect of Antisense Oligonucleotide Developed Against the Common 3′ NCR of Influenza A Virus Genome

@article{Kumar2013CrossProtectiveEO,
  title={Cross-Protective Effect of Antisense Oligonucleotide Developed Against the Common 3′ NCR of Influenza A Virus Genome},
  author={Prashant Kumar and Binod Kumar and Roopali Rajput and Latika Saxena and A. C. Banerjea and Madhu Khanna},
  journal={Molecular Biotechnology},
  year={2013},
  volume={55},
  pages={203-211}
}
The influenza A virus (IAV) has eight segmented single-stranded RNA genome containing a common and evolutionarily conserved non-coding region (NCRs) at 5′ and 3′ ends that are important for the virus replication. In this study, we designed an antisense oligonucleotide against the 3′ NCR of vital segments of the IAV genome to inhibit its replication. The results demonstrated that the co-transfection of Madine Darby Canine Kidney (MDCK) cells with the antisense oligonucleotide and the plasmids… Expand
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