Cross-Linking and Intracorneal Ring Segments—Review of the Literature

@article{AvniZauberman2014CrossLinkingAI,
  title={Cross-Linking and Intracorneal Ring Segments—Review of the Literature},
  author={Noa Avni-Zauberman and David S. Rootman},
  journal={Eye \& Contact Lens: Science \& Clinical Practice},
  year={2014},
  volume={40},
  pages={365–370}
}
Objectives: To review and summarize relevant studies on combined use of corneal crosslinking and intracorneal ring segments (ICRS) for the treatment of corneal ectasia. Methods: A literature search was performed using the key words “corneal collagen cross-linking” and “intra-corneal ring segments.” Results: Crosslinking is a well-accepted treatment option for corneal ectasia and can be combined with corneal ICRS insertion as needed. The advent of crosslinking has dramatically reduced the number… 
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References

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Intracorneal ring segments in ectatic corneal disease – a review
TLDR
ICRS technology is a promising therapeutic option in corneal ectatic disease, avoidingCorneal graft and allowing a visual and refractive rehabilitation, according to the evidence found in the peer‐reviewed literature.
Collagen Crosslinking for Keratoconus
TLDR
This study showed that crosslinking was effective in halting the progression of keratoconus over a period of 4 years, with varying degrees of improvement in visual acuity and reduction in keratometry with a progressive trend in improvement depending on the duration of follow-up.
Intacs with or without same-day corneal collagen cross-linking to treat corneal ectasia.
Intracorneal Ring Segment Explantation After Intracorneal Ring Segment Implantation Combined With Same-Day Corneal Collagen Crosslinking in Keratoconus
TLDR
Despite the reversal of refractive outcomes, the preservation of topographic changes may occur in some cases after the explantation of 1 or both the segments in patients with keratoconus treated with ICRS implantation with same-day CXL.
Sequential versus concurrent KERARINGS insertion and corneal collagen cross-linking for keratoconus
TLDR
Combined KERARINGS insertion and CXL can be performed safely in one or two sessions, however, the same-session procedure appears to be more effective regarding the improvement in the corneal shape.
Intracorneal ring segments implantation followed by same-day photorefractive keratectomy and corneal collagen cross-linking in keratoconus.
TLDR
The combination of intracorneal ring segments implantation followed by sequential same-day PRK/CXL may be a reasonable option for improving visual acuity in select patients with keratoconus.
Corneal Collagen Cross-Linking Before Ferrara Intrastromal Corneal Ring Implantation for the Treatment of Progressive Keratoconus
TLDR
FR implantation after CXL is a safe and efficacious treatment option for managing selected patients with progressive keratoconus and good results in terms of visual acuity, postoperative residual refractive error, and keratometry values were obtained.
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