Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion.

@article{Hu2005CrossGP,
  title={Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion.},
  author={Hailan Hu and M Li and J Labrador and Jason McEwen and Eric C. Lai and Corey S. Goodman and Greg J Bashaw},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 12},
  pages={4613-8}
}
The regulators of the Rho-family GTPases, GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs), play important roles in axon guidance. By means of a functional genomic study of the Rho-family GEFs and GAPs in Drosophila, we have identified a Rho-family GAP, CrossGAP (CrGAP), which is involved in Roundabout (Robo) receptor-mediated repulsive axon guidance. CrGAP physically associates with the Robo receptor. Too much or too little CrGAP activity leads to defects in Robo-mediated… CONTINUE READING