Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma.

@article{Rajbhandari2018CrossCohortAI,
  title={Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma.},
  author={Presha Rajbhandari and Gonzalo L{\'o}pez and Claudia Capdevila and Beatrice Salvatori and Jiyang Yu and Ruth Rodr{\'i}guez-Barrueco and Daniel Martinez and Mark Yarmarkovich and Nina Weichert-Leahey and Bulgaria Campero Abraham and M. Jes{\'u}s Alvarez and Archana Iyer and Jo Lynne Harenza and Derek A Oldridge and Katleen De Preter and Jacko Koster and Shahab Asgharzadeh and Robert C. Seeger and Jun S Wei and Javed Arif Khan and Jo Vandesompele and Pieter Mestdagh and Rogier Versteeg and A. Thomas Look and Richard A Young and Antonio Iavarone and Anna Lasorella and Jos{\'e} M.P. Silva and John M. Maris and Andrea Califano},
  journal={Cancer discovery},
  year={2018},
  volume={8 5},
  pages={
          582-599
        }
}
High-risk neuroblastomas show a paucity of recurrent somatic mutations at diagnosis. As a result, the molecular basis for this aggressive phenotype remains elusive. Recent progress in regulatory network analysis helped us elucidate disease-driving mechanisms downstream of genomic alterations, including recurrent chromosomal alterations. Our analysis identified three molecular subtypes of high-risk neuroblastomas, consistent with chromosomal alterations, and identified subtype-specific master… CONTINUE READING
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