Cross‐species models of human melanoma

  title={Cross‐species models of human melanoma},
  author={Louise van der Weyden and E Elizabeth Patton and Geoffrey A Wood and Alastair K Foote and Thomas Brenn and David J. Adams},
  booktitle={The Journal of pathology},
Although transformation of melanocytes to melanoma is rare, the rapid growth, systemic spread, as well as the chemoresistance of melanoma present significant challenges for patient care. Here we review animal models of melanoma, including murine, canine, equine, and zebrafish models, and detail the immense contribution these models have made to our knowledge of human melanoma development, and to melanocyte biology. We also highlight the opportunities for cross-species comparative genomic… CONTINUE READING
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