Cross‐reactivity with myelin basic protein and human herpesvirus‐6 in multiple sclerosis

@article{TejadaSimon2003CrossreactivityWM,
  title={Cross‐reactivity with myelin basic protein and human herpesvirus‐6 in multiple sclerosis},
  author={Maria Victoria Tejada-Simon and Ying C. Q. Zang and Jian Hong and Victor M. Rivera and Jingwu Z. Zhang},
  journal={Annals of Neurology},
  year={2003},
  volume={53}
}
Viral infections are though to play an important role in the pathogenesis of multiple sclerosis (MS) potentially through molecular mimicry. An identical sequence was found in both myelin basic protein (MBP, residues 96–102), a candidate autoantigen for MS, and human herpesvirus‐6 (HHV‐6 U24, residues 4–10) that is a suspected viral agent associated with MS. In this study, we showed that greater than 50% of T cells recognizing MBP93‐105 cross‐reacted with and could be activated by a synthetic… 
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