Cross‐reaction patterns in patients with contact allergy to simple methylol phenols

  title={Cross‐reaction patterns in patients with contact allergy to simple methylol phenols},
  author={Magnus Bruze and Erik Zimerson},
  journal={Contact Dermatitis},
The low‐molecular‐weight phenols 2‐methylol phenol (2‐MP), 4‐methylol phenol (4‐MP), 2,4,6‐trimethylol phenol (2,4,6‐MP), 3‐methylol phenol (3‐MP), 2,4‐dimethylol phenol (2,4‐MP), and 2,6‐dimethylol phenol (2,6‐MP) are contact sensitizers in resins leased on phenol and formaldehyde (P‐F‐R). Other chemically related low‐molecular‐weight phenols are common in the environment. In patients hypersensitive to P‐F‐R and MPs, it is for diagnostic, therapeutic and preventive reasons necessary to know… Expand
Severe adverse cutaneous reaction to insulin due to cresol sensitivity
An 80‐year‐old lady known to be sensitive to chlorocresol who developed severe erythrodermic exfoliative dermatitis with atypical features 2 weeks after commencing subcutaneous insulin died, and it is hypothesize that the adverse cutaneous reaction was a systemic manifestation of cresol sensitivity. Expand
Occupational airborne allergic contact dermatitis from medium‐density fibreboard containing phenol‐formaldehyde resin‐2 (PFR‐2)
A 49-year-old carpenter with no prior history of skin disease presented with an 8-week history of an itchy erythematous vesicular rash involving his face and neck has had no further recurrences of eczema since avoiding MDF at work. Expand
Demonstration of the contact sensitizer p-tert-butylcatechol in p-tert-butylphenol formaldehyde resin.
  • E. Zimerson, M. Bruze
  • Chemistry, Medicine
  • American journal of contact dermatitis : official journal of the American Contact Dermatitis Society
  • 1999
The study indicates that a positive patch test reaction to PTBP-F-R could be an indication of allergy to PTBC, at least in patients with high sensitivity toPTBC. Expand
Sensitizing capacity of Disperse Orange 1 and its potential metabolites from azo reduction and their cross‐reactivity pattern
Some metabolites from the azo reduction of these disperse azo dyes could be sensitizers, as human skin bacteria produce azo reductases. Expand
Allergic contact dermatitis from salicyl alcohol and salicylaldehyde in aspen bark (Populus tremula)
An elk researcher who had handled leaves from various trees presented with eczema of the hands, face, flexures, trunk and extremities, and a second case with concomitant allergy to salicylaldehyde is described. Expand
Immunomodulatory effects of mono-, di-, and trimethylphenols in mice.
Several methylphenols, especially dimethylphenol isomers, have potencies that affect the immune system, being immunogens themselves or modulators of the Th1/Th2 cytokine balance. Expand
Determinação de fenol urinário por cromatografia em fase gasosa em trabalhadores que utilizam resinas fenólicas em fundições
Phenol is used as an industrial chemical, disinfectant agent, in the preparation of phenolic resins and paint pigments. When in solid state, it shows a light pink color, ocre odor, and isExpand
Contact allergy to textile dyes
Disperse dyes are the most common allergens among textile dyes. It is not known whether the purified dyes, impurities in the commercial dyes, or metabolites are the actual sensitisers. Moreover, itExpand
Final Report on the Safety Assessment of Benzaldehyde1
  • A. Andersen
  • Chemistry, Medicine
  • International journal of toxicology
  • 2006
The available dermal irritation and sensitization data and ultraviolet (UV) absorption and phototoxicity data demonstrating no adverse reactions to Benzoic Acid support the safety of Benzaldehyde as currently used in cosmetic products. Expand


Demonstration of contact sensitizers in resins and products based on phenol‐formaldehyde
The highest concentrations (up to 15% w/w) of allergens were noted for methylol phenols in resol resins based on phenol and formaldehyde, and the corresponding novolak resins showed d high content of dihydroxydiphenyl methanes. Expand
Contact allergy to 3-methylol phenol, 2,4-dimethylol phenol and 2,6-dimethylol phenol.
Chemical investigation by high pressure liquid chromatography indicated that the compounds tested were pure and separable and there has been chromatographic evidence of 3-methylol phenol in the P-F-R used in the routine test series at the department. Expand
Sensitizing capacity of 2‐methylol phenol, 4‐methylol phenol and 2, 4, 6‐trimethylol phenol in the guinea pig
  • M. Bruze
  • Chemistry, Medicine
  • Contact dermatitis
  • 1986
The sensitizing capacities of 2‐ methylol phenol (2‐MP), 4‐methylolphenol (4‐MP) and 2,4,6‐inmethylol phenols (2,4‐6‐ MP) were investigated with the guinea pig maximization test in order to assess and compare the degree of the sensitization capacities of these chemically related substances. Expand
Contact allergy to phenol‐formaldehyde resins
A battery of phenol‐formaldehyde resins should be used for screening purposes, since patch testing with the paratertiary‐butyl phenol-formaldehyde resin is not sufficient to identify patients with contact allergy to phenol •formaldehyde Resins. Expand
Contact sensitization to 2‐monomethylol phenol in phenol formaldehyde resin as an example of the recognition and prevention of industrial dermatoses *
  • R. Rycroft
  • Chemistry, Medicine
  • Clinical and experimental dermatology
  • 1982
Attention is drawn to the potential significance of 2‐monomethylol phenol (2‐MMP) as a contact sensitizer in phenol formaldehyde resins. Expand
p-tert.-Butylphenol formaldehyde and other causes of shoe dermatitis.
Because p-tert.-butylphenolformaldehyde-free shoes are unavailable in the Dutch market, shoes made of alternative materials for 13 patients reacting to this resin were made, and only one patient reacted to virtually all materials tested. Expand
Phenolformaldehyde resin in paper
In this patient, the localization of the pustules, the regular exacerbation in summer, and the absence of other skin lesions made us suspect contact allergy. Expand
Comparison of Phenols in Smokes of Lamina and Midrib of Flue-cured Tobacco
In order to reveal the difference of the main stream smoke composition between lamina and midrib of flue-cured tobacco, the yields of neutral, basic, acidic and phenolic fractions of the smokeExpand
Quantitative Analysis of Cigarette Smoke Condensate Monophenols by Reverse-Phase High-Performance Liquid Chromatography
Abstract A rapid and quantitative method for the determination of cigarette smoke condensate monophenols using high-performance liquid chromatography (HPLC) was developed. Total particulate matterExpand
Incorrect declaration of potential photosensitizing compounds.