Cross‐Reactivity of Sperm and T Lymphocyte Antigens *

  title={Cross‐Reactivity of Sperm and T Lymphocyte Antigens *},
  author={Subbi P Mathur and Jean Michel Goust and H. Oliver Williamson and Hugh H. Fudenberg},
  journal={American Journal of Reproductive Immunology},
ABSTRACT: Evidence is presented for cross‐reactivity between antigens on human sperm and T lymphocytes. In 25 infertile couples in which both the males and females had significant antisperm immunity, antibody (Ab) titers to thymocytes (mean ± S.E.M. 159 ±4 and 72 ± 14, respectively, in males and females), T cell lines CCRF‐CEM (69±5 and 48±8) and HSB‐2 (56±15) and 41±8), suppressorenriched (TG) cells (26±6 and 66±28) and helper‐enriched (Tg—) cells (26±4 and 46±14) were significantly elevated… 
Sperm Immunity in Infertile Couples: Antibody Titers Are Higher Against the Husbands' Sperm Than to Sperm From Controls *
ABSTRACT: Titers of hemagglutination and cytotoxic antibodies to sperm were determined in the sera, seminal plasma, cervical mucus, and vaginal secretions from 69 infertile couples, using sperm from
Antibodies to microbial, leukocyte and organ antigens.
It is shown that healthy homosexual men possess sperm antibodies, T-lymphocyte antibodies and circulating immune complexes containing sperm antigen and that a male rabbit model system is developed to directly assess the immunological consequences of rectal semen deposition.
Fetal Cytotoxic Antibodies to Maternal T Lymphocytes: A Possible Mechanism for Maternal Tolerance of the Fetal Allograft *
  • S. Mathur, H. Fudenberg, M. Keane, P. Rust, H. Williamson
  • Medicine, Biology
    American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction
  • 1982
It is concluded that the fetus produces lymphocytotoxic antibody specifically directed against maternal T lymphocytes, in addition to antibody against T lymphocyte of other adults.
Chronic immune stimulation by sperm alloantigens. Support for the hypothesis that spermatozoa induce immune dysregulation in homosexual males.
It is suggested that chronic, repeated exposure to sperm during anal intercourse results in a high frequency of allogeneic immunization and may play an important role in the development of acquired immune dysregulation among homosexual males.
Heterogeneity in the presence of CD4‐like molecules on human spermatozoa
There is evidence of heterogeneity in the presence of CD4‐like antigen determinants on human spermatozoa from fertile donors and infertile patients, and data from the experiments carried out increase the information about theCD4‐antigen characteristic of the spermatoza from fertile donor and infERTile patients.
Special antigens on sperm from autoimmune infertile men.
Sera from fertile men reacted against common antigens with molecular weights present on sperm from autoimmune and nonautoimmune men and special antigen of MW 76 kD on the sperm of fertile men in addition to the commonAntigens.
Semen alloantigens and lymphocytotoxic antibodies in AIDS and ICL
Data prove that immunologic exposure to sperm and lymphocytes is theoretically capable of initiating lymphocytotoxic autoimmunity and will need to be addressed clinically in high risk individuals regardless of HIV status and regardless of the success of anti-HIV prophylaxis and treatment.


Human T Cell Subpopulations in Normal and Pathologic Conditions
T cells bearing Ly 1 alloantigen show a helper activity in both the antibody response, and in the generation of cytotoxic T lymphocytes (CTL) respond to determinants coded for by the I and S regions in mixed lymphocyte reactions (MLR) and are the effector cells in delayed-type hypersensitivity reactions.
Demonstration of IgG Fc receptors on spermatozoa and their utilization for the detection of circulating immune complexes in human serum.
Sperm assays detected soluble immune complexes in sera of vasectomized males, cancer patients and patients with autoimmune or dermatological diseases and yields values for immune complex determination both comparable and complementary to the Raji cell radioimmunoassay.
Inhibition of In Vitro Immune Responses by a Fraction from Seminal Plasma
The inhibitory effects of a fraction of bovine seminal plasma on in vitro lymphocyte responses to specific and nonspecific ligands are studied and the importance of the present findings for the immunophysiology of reproduction are discussed.
Reactivity of anti-human brain serum with human lymphocytes.
  • T. Whiteside
  • Biology, Medicine
    The American journal of pathology
  • 1977
The antiserum was used in studies of lymphocytes in chronic and acute lymphocytic leukemias, lymphomas, and other lymphoproliferative diseases as numbers and distribution in the circulation, spleen and nodes of lymphocyte bearing the T marker were significantly altered in patients with these disorders.