Crohn's disease

@article{Shanahan2002CrohnsD,
  title={Crohn's disease},
  author={F. Shanahan},
  journal={The Lancet},
  year={2002},
  volume={359},
  pages={62-69}
}
Crohn's disease is a disorder mediated by T lymphocytes which arises in genetically susceptible individuals as a result of a breakdown in the regulatory constraints on mucosal immune responses to enteric bacteria. Regulation of immune reactivity to enteric antigens has improved understanding of the pathophysiological mechanisms of Crohn's disease, and has expanded therapeutic options for patients with this disorder. Disease heterogeneity is probable, with various underlying defects associated… Expand
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