178 Citations
Overview of role of the immune system in the pathogenesis of inflammatory bowel disease.
- Medicine, BiologyAdvances in experimental medicine and biology
- 2006
Analysis of the types of immune responses ongoing in diseased mucosa of inflammatory bowel disease patients has revealed that CD and UC are fundamentally different diseases.
Transplanting the genetic susceptibility to Crohn’s disease
- Biology, MedicineGut
- 2003
Clinical and experimental evidence for the role of distinct mononuclear cell populations has been limited, and aetiological aspects are reconciled in a paradigm, in which CD could result from disturbances of the intestinal barrier and pathological activation of the intestine immune response towards luminal bacterial antigens in individuals with genetic susceptibility.
New Biologic Drugs for Ulcerative Colitis
- Biology, Medicine
- 2011
The mechanism of action and the efficacy of biological agent in UC are reviewed and a number of biological agents that selectively target specific molecules and pathway involve in gut inflammation are developed.
Biologic Therapy for Inflammatory Bowel Disease
- Biology, MedicineDrugs
- 2012
The mucosal immune system is the central effector of intestinal inflammation and injury, with cytokines playing a central role in modulating inflammation, and Cytokines may be a logical target for IBD therapy using specific cytokine inhibitors.
Pathophysiology of inflammatory bowel disease: an overview.
- MedicineThe Surgical clinics of North America
- 2007
Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response?
- Medicine, BiologyLaboratory Investigation
- 2005
The results suggest that the noncaseating granulomas could be one of the crucial sites of Th1-shifted immune responses in Crohn's disease.
The Gastroenterologist’s Update on Inflammatory Bowel Diseases
- Medicine
- 2003
Idiopathic inflammatory bowel disease (IBD) includes a collection of disorders of the gastrointestinal tract of unknown aetiology, characterized by intestinal inflammation and a chronic relapsing…
Crohn's colitis in infancy.
- MedicineAnnals of Saudi medicine
- 2003
A case of Crohns colitis is reported because it is rare at this age and appeared at the hospital in an infant for the first time and is reported to be 3-4/100 000.
Mechanisms and Efficacy of Immunobiologic Therapies for Inflammatory Bowel Diseases
- Medicine, BiologyInternational reviews of immunology
- 2010
Immunobiologic agents targeted against TNF, leukocyte adhesion, Th1 polarization, T cell activation, nuclear factor-kappaB (NF-ÎşB), and others are being assessed and will open exciting perspectives on development of therapies for inflammatory bowel disease.
Enteral nutrition in the management of Crohn's disease.
- MedicineJPEN. Journal of parenteral and enteral nutrition
- 2005
This workshop aims to examine possible mechanisms of action of enteral nutrition as primary therapy, and to make evidence-based recommendations concerning its use in the new era of biologic therapies, when mucosal healing has become a realistic goal.
References
SHOWING 1-10 OF 66 REFERENCES
Immunological and genetic links in Crohn's disease
- MedicineGut
- 2000
Current consensus holds that the pathogenesis of Crohn's disease involves the interacting elements of multigenic host susceptibility factors and environmental priming from the enteric microflora.
Ulcerative colitis and Crohn's disease
- MedicineBMJ
- 1994
In a total of 1812 pages 156 contributors provide detailed accounts of the recent striking rise in the incidence of Crohn's disease but not ulcerative colitis in most developed countries; patients' genetic disposition; and clinical features, immunology, pathology, complications, and management options.
Measles Virus and Crohn's Disease: A Critical Appraisal of the Current Literature
- MedicineInflammatory bowel diseases
- 2001
The current literature does not support an association between measles virus and IBD, and the well-accepted Bradford-Hill criteria is used to evaluate the possible causal association.
Therapeutic Manipulation of Gut Flora
- Biology, MedicineScience
- 2000
In his Perspective, Shanahan discusses a new therapeutic approach to treating inflammatory bowel disease in which bacteria normally found in the gut are engineered to produce the anti-inflammatory cytokine interleukin-10 and then are fed as probiotics to mice with these disorders.
Animal models of mucosal inflammation and their relation to human inflammatory bowel disease.
- BiologyCurrent opinion in immunology
- 1999
Inflammatory bowel disease: immunodiagnostics, immunotherapeutics, and ecotherapeutics.
- MedicineGastroenterology
- 2001
Although most drug treatments are directed toward altering the host response, the rationale for manipulating the enteric flora appears sound and will be the basis of additional future therapeutic strategies.
The resident faecal flora is determined by genetic characteristics of the host. Implications for Crohn's disease?
- MedicineAntonie van Leeuwenhoek
- 2004
It is concluded that the resident faecal flora is under genetic influence and may be a useful parameter to study possible genetic backgrounds of other diseases.
Does the failure to acquire helminthic parasites predispose to Crohn's disease?
- Medicine, BiologyFASEB journal : official publication of the Federation of American Societies for Experimental Biology
- 2000
It is proposed that exposure to an environmental agent predisposes individuals to Crohn's disease and the Th2 response provoked by parasitic worms can modulate immune reactions to unrelated parasitic, bacterial, and viral infections.