Crohn's disease

@article{Shanahan2002CrohnsD,
  title={Crohn's disease},
  author={Fergus Shanahan},
  journal={The Lancet},
  year={2002},
  volume={359},
  pages={62-69}
}
  • F. Shanahan
  • Published 5 January 2002
  • Medicine, Biology
  • The Lancet
Overview of role of the immune system in the pathogenesis of inflammatory bowel disease.
TLDR
Analysis of the types of immune responses ongoing in diseased mucosa of inflammatory bowel disease patients has revealed that CD and UC are fundamentally different diseases.
Transplanting the genetic susceptibility to Crohn’s disease
TLDR
Clinical and experimental evidence for the role of distinct mononuclear cell populations has been limited, and aetiological aspects are reconciled in a paradigm, in which CD could result from disturbances of the intestinal barrier and pathological activation of the intestine immune response towards luminal bacterial antigens in individuals with genetic susceptibility.
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TLDR
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TLDR
The mucosal immune system is the central effector of intestinal inflammation and injury, with cytokines playing a central role in modulating inflammation, and Cytokines may be a logical target for IBD therapy using specific cytokine inhibitors.
Pathophysiology of inflammatory bowel disease: an overview.
Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response?
TLDR
The results suggest that the noncaseating granulomas could be one of the crucial sites of Th1-shifted immune responses in Crohn's disease.
The Gastroenterologist’s Update on Inflammatory Bowel Diseases
Idiopathic inflammatory bowel disease (IBD) includes a collection of disorders of the gastrointestinal tract of unknown aetiology, characterized by intestinal inflammation and a chronic relapsing
Crohn's colitis in infancy.
TLDR
A case of Crohns colitis is reported because it is rare at this age and appeared at the hospital in an infant for the first time and is reported to be 3-4/100 000.
Mechanisms and Efficacy of Immunobiologic Therapies for Inflammatory Bowel Diseases
TLDR
Immunobiologic agents targeted against TNF, leukocyte adhesion, Th1 polarization, T cell activation, nuclear factor-kappaB (NF-κB), and others are being assessed and will open exciting perspectives on development of therapies for inflammatory bowel disease.
Enteral nutrition in the management of Crohn's disease.
  • A. Griffiths
  • Medicine
    JPEN. Journal of parenteral and enteral nutrition
  • 2005
TLDR
This workshop aims to examine possible mechanisms of action of enteral nutrition as primary therapy, and to make evidence-based recommendations concerning its use in the new era of biologic therapies, when mucosal healing has become a realistic goal.
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References

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Immunological and genetic links in Crohn's disease
TLDR
Current consensus holds that the pathogenesis of Crohn's disease involves the interacting elements of multigenic host susceptibility factors and environmental priming from the enteric microflora.
Ulcerative colitis and Crohn's disease
TLDR
In a total of 1812 pages 156 contributors provide detailed accounts of the recent striking rise in the incidence of Crohn's disease but not ulcerative colitis in most developed countries; patients' genetic disposition; and clinical features, immunology, pathology, complications, and management options.
Measles Virus and Crohn's Disease: A Critical Appraisal of the Current Literature
TLDR
The current literature does not support an association between measles virus and IBD, and the well-accepted Bradford-Hill criteria is used to evaluate the possible causal association.
Therapy of inflammatory bowel disease.
  • B. Sands
  • Medicine, Biology
    Gastroenterology
  • 2000
Therapeutic Manipulation of Gut Flora
TLDR
In his Perspective, Shanahan discusses a new therapeutic approach to treating inflammatory bowel disease in which bacteria normally found in the gut are engineered to produce the anti-inflammatory cytokine interleukin-10 and then are fed as probiotics to mice with these disorders.
Inflammatory bowel disease: immunodiagnostics, immunotherapeutics, and ecotherapeutics.
TLDR
Although most drug treatments are directed toward altering the host response, the rationale for manipulating the enteric flora appears sound and will be the basis of additional future therapeutic strategies.
The resident faecal flora is determined by genetic characteristics of the host. Implications for Crohn's disease?
TLDR
It is concluded that the resident faecal flora is under genetic influence and may be a useful parameter to study possible genetic backgrounds of other diseases.
Does the failure to acquire helminthic parasites predispose to Crohn's disease?
TLDR
It is proposed that exposure to an environmental agent predisposes individuals to Crohn's disease and the Th2 response provoked by parasitic worms can modulate immune reactions to unrelated parasitic, bacterial, and viral infections.
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