Crohn's disease: the cold chain hypothesis

@article{Hugot2003CrohnsDT,
  title={Crohn's disease: the cold chain hypothesis},
  author={J. Hugot and C. Alberti and D. Berrebi and E. Bingen and J. C{\'e}zard},
  journal={The Lancet},
  year={2003},
  volume={362},
  pages={2012-2015}
}
Crohn's disease is the result of an abnormal immune response of the gut mucosa triggered by one or more environmental risk factors in people with predisposing gene variations, including CARD15 mutations. Epidemiological data allow assessment of familial environmental risk factors related to western lifestyle, diet, bacteria, and domestic hygiene. All findings point to refrigeration as a potential risk factor for Crohn's disease. Furthermore, cold-chain development paralleled the outbreak of… Expand
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