Crohn's disease: the cold chain hypothesis

@article{Forbes2005CrohnsDT,
  title={Crohn's disease: the cold chain hypothesis},
  author={Alastair Forbes and Tommy Kalantzis},
  journal={International Journal of Colorectal Disease},
  year={2005},
  volume={21},
  pages={399-401}
}
A recent published hypothesis proposed that Crohn's disease was provoked by infantile exposure to micro-organisms that can survive refrigerator temperature. A case–control study was accordingly devised. The mean age at first fridge was 5.6 years amongst 88 patients with Crohn's disease, 5.5 years in 88 patients with ulcerative colitis (UC) and 7.6 years in 88 controls, but a majority of individuals had always been exposed to refrigerated food. Differences were more striking in subjects aged… 
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11 Citations
Background Citations
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Results Citations
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11 Citations

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Citation Type

Crohn’s Disease: Is the Cold Chain Hypothesis Still Hot?
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Both appendectomy and tonsillectomy were risk factors in CD in this study, and current smoking was a significant protective factor in UC.
Risk factors for inflammatory bowel diseases according to the "hygiene hypothesis": a case-control, multi-centre, prospective study in Southern Italy.
Environmental Triggers for IBD
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The environmental influences are placed in the context of their potential contribution to the development of the pathophysiology of IBD to achieve a greater understanding of the contribution of these factors to dysbiosis and aspire to restoring a healthy microbiome to treat flares and ideally prevent the development and its complications.
Terminal Ileitis due to Yersinia Infection: An Underdiagnosed Situation
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The most important data regarding the various aspects of Yersinia infection are reviewed with special focus on its pathophysiology and diagnosis, including testing for serum antibodies against YOP antigens in all patients with an endoscopic and histological image of terminal ileitis.
Hospitalization frequency caused by inflammatory bowel disease in rural and urban inhabitants
TLDR
There has been a significant increase of patients with inflammatory bowel disease in the last decade, and the patients originating in urban areas were more frequent than those from rural regions, and this may be related to environmental differences between these two population groups.
European Crohn’s and Colitis Organisation Topical Review on Environmental Factors in IBD
This ECCO Topical Review of the European Crohn's and Colitis Organisation [ECCO] focuses on the role of environmental factors with respect to the development of inflammatory bowel disease [IBD] as…
Progress in Our Understanding of the Gut Microbiome: Implications for the Clinician
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Clinical important examples of a central role for microbiota-host interactions in disease pathogenesis have emerged and many more have been postulated but await confirmation in appropriately powered and conducted studies.
Urbanization and the gut microbiota in health and inflammatory bowel disease
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The disparate patterns of the gut microbiota composition in rural and urban areas offer an opportunity to understand the contribution of a ‘rural microbiome’ in potentially protecting against the development of IBD.
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References

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Crohn's disease: the cold chain hypothesis
The differential diagnosis of idiopathic inflammatory disease by colorectal biopsy
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  • Medicine
    International Journal of Colorectal Disease
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TLDR
Interaction between the endoscopist and pathologist is essential in optimizing the contribution of colorectal biopsy to management of patients with inflammatory bowel disease.