Crohn's disease: the cold chain hypothesis

@article{Forbes2005CrohnsDT,
  title={Crohn's disease: the cold chain hypothesis},
  author={Alastair Forbes and Tommy Kalantzis},
  journal={International Journal of Colorectal Disease},
  year={2005},
  volume={21},
  pages={399-401}
}
A recent published hypothesis proposed that Crohn's disease was provoked by infantile exposure to micro-organisms that can survive refrigerator temperature. A case–control study was accordingly devised. The mean age at first fridge was 5.6 years amongst 88 patients with Crohn's disease, 5.5 years in 88 patients with ulcerative colitis (UC) and 7.6 years in 88 controls, but a majority of individuals had always been exposed to refrigerated food. Differences were more striking in subjects aged… 
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References

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Crohn's disease: the cold chain hypothesis
The differential diagnosis of idiopathic inflammatory disease by colorectal biopsy
  • S. Hamilton
  • Medicine
    International Journal of Colorectal Disease
  • 2005
TLDR
Interaction between the endoscopist and pathologist is essential in optimizing the contribution of colorectal biopsy to management of patients with inflammatory bowel disease.