Crohn's disease: innate immunodeficiency?

  title={Crohn's disease: innate immunodeficiency?},
  author={Jes{\'u}s K Yamamoto-Furusho and Joshua-R Korzenik},
  journal={World journal of gastroenterology},
  volume={12 42},
In the past, Crohn's disease (CD) has been understood primarily as an immunologic disorder characterized by an abnormal T-cell response. Recent in vitro and in vivo data suggests that CD may instead be precipitated by innate immune dysfunction resulting from a combination of genetic and environmental factors. Some reports have demonstrated a defective immune response in a variety of other cellular components, including neutrophils, monocytes and dendritic cells. Recent studies of granulocyte… CONTINUE READING

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