Crohn’s Disease and SLC11A1 Promoter Polymorphism

  title={Crohn’s Disease and SLC11A1 Promoter Polymorphism},
  author={Irit Chermesh and Aviva Azriel and Michal Alter-Koltunoff and R. Eliakim and Amir Karban and Ben-Zion Levi},
  journal={Digestive Diseases and Sciences},
Crohn’s disease (CD) is a chronic multifactorial inflammatory disease. The prevalence of CD in Ashkenazi Jews is higher than in Sephardic Jews. SLC11A1, also known as Nramp1, is a divalent cation antiporter essential for the elimination of intraphagosomal pathogens. SLC11A1 has seven alleles in the promoter region and previous studies have suggested an association between CD and SLC11A1. The aim of this study was to check for a possible association between SLC11A1 promoter alleles and CD in… 
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