Crofelemer for the treatment of secretory diarrhea

  title={Crofelemer for the treatment of secretory diarrhea},
  author={Jessica M. Cottreau and Anne M Tucker and Rustin D. Crutchley and Kevin W. Garey},
  journal={Expert Review of Gastroenterology \& Hepatology},
  pages={17 - 23}
Secretory diarrhea is a leading cause of morbidity and mortality worldwide. Crofelemer is a first-in-class antidiarrheal agent that simultaneously targets two distinct channels, the cystic fibrosis conductance regulator and calcium-activated chloride channel, responsible for chloride and fluid secretion in the GI tract. Crofelemer is a novel compound extracted from the stem bark latex of the Croton lechleri tree found in the western Amazonian region of South America. There is little to no… 
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Improved Electrolyte and Fluid Balance Results in Control of Diarrhea with Crofelemer in Patient with Short Bowel Syndrome: A Case Report
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    Journal of Clinical Gastroenterology and Treatment
  • 2022
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Crofelemer, an Antisecretory Antidiarrheal Proanthocyanidin Oligomer Extracted from Croton lechleri, Targets Two Distinct Intestinal Chloride Channels
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    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
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