Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of alpha-tocopherol.

@article{Ochiai2004CrocinPT,
  title={Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of alpha-tocopherol.},
  author={Takashi Ochiai and Shigekazu Ohno and Shinji Soeda and Hiroyuki Tanaka and Yukihiro Shoyama and Hiroshi Shimeno},
  journal={Neuroscience letters},
  year={2004},
  volume={362 1},
  pages={61-4}
}
Crocin is a pharmacologically active component of Crocus sativus L. (saffron) used in traditional Chinese medicine. We report here the effects of crocin on neuronally differentiated pheochromocytoma (PC-12) cells deprived of serum/glucose. Depriving the PC-12 cells of serum/glucose caused peroxidation of their cell membrane lipids and decreased intercellular superoxide dismutase (SOD) activity. Treating the PC-12 cells with 10 microM crocin inhibited the formation of peroxidized lipids, partly… CONTINUE READING

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