Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells.

@article{Brbek2005CrkassociatedST,
  title={Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells.},
  author={Jan Br{\'a}bek and S{\'a}bata S Constancio and Priscila Fonseca Siesser and Nah-Young Shin and Ambra Pozzi and Steven K Hanks},
  journal={Molecular cancer research : MCR},
  year={2005},
  volume={3 6},
  pages={307-15}
}
Crk-associated substrate (CAS, p130Cas) is a major tyrosine phosphorylated protein in cells transformed by v-crk and v-src oncogenes. We recently reported that reexpression of CAS in CAS-deficient mouse embryo fibroblasts transformed by oncogenic Src promoted an invasive phenotype associated with enhanced cell migration through Matrigel, organization of actin into large podosome ring and belt structures, activation of matrix metalloproteinase-2, and elevated tyrosine phosphorylation of the… CONTINUE READING