Crk-associated substrate lymphocyte type regulates myeloid cell motility and suppresses the progression of leukemia induced by p210Bcr/Abl.

@article{Seo2011CrkassociatedSL,
  title={Crk-associated substrate lymphocyte type regulates myeloid cell motility and suppresses the progression of leukemia induced by p210Bcr/Abl.},
  author={Sachiko Seo and Tetsuya Nakamoto and Masataka Takeshita and Jun Lu and Tomohiko Sato and Takahiro Suzuki and Yasuhiko Kamikubo and Motoshi Ichikawa and Masaki Noda and Seishi Ogawa and Hiroaki Honda and Hideaki Oda and Mineo Kurokawa},
  journal={Cancer science},
  year={2011},
  volume={102 12},
  pages={
          2109-17
        }
}
The p210Bcr/Abl and p190Bcr/Abl fusion oncoproteins are known to cause chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Bcr/Abl phosphorylates several proteins that can lead to leukemogenesis. Crk-associated substrate lymphocyte type (Cas-L)/human enhancer of filamentation-1 (HEF1)/neural precursor cell expressed, developmentally down-regulated 9 (NEDD9) is an adapter protein at focal adhesions known to be associated with solid tumor metastasis. Crk-associated… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

Similar Papers

Loading similar papers…