Crizotinib versus chemotherapy in advanced ALK-positive lung cancer.

@article{Shaw2013CrizotinibVC,
  title={Crizotinib versus chemotherapy in advanced ALK-positive lung cancer.},
  author={Alice Tsang Shaw and Dong-Wan Kim and Kazuhiko Nakagawa and Takashi Seto and Lucio Crin{\`o} and Myung-ju Ahn and Tommaso Martino de Pas and Benjamin Besse and Benjamin J. Solomon and Fiona Blackhall and Yi-Long Wu and Michael Thomas and Kenneth J O'byrne and Denis L Moro-Sibilot and David Ross Camidge and Tony C. W. Mok and Vera Hirsh and Gregory J Riely and Shrividya S Iyer and Vanessa Tassell and A. D. Polli and Keith David Wilner and Pasi Antero J{\"a}nne},
  journal={The New England journal of medicine},
  year={2013},
  volume={368 25},
  pages={
          2385-94
        }
}
BACKGROUND In single-group studies, chromosomal rearrangements of the anaplastic lymphoma kinase gene (ALK) have been associated with marked clinical responses to crizotinib, an oral tyrosine kinase inhibitor targeting ALK. Whether crizotinib is superior to standard chemotherapy with respect to efficacy is unknown. METHODS We conducted a phase 3, open-label trial comparing crizotinib with chemotherapy in 347 patients with locally advanced or metastatic ALK-positive lung cancer who had… CONTINUE READING

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