Crizotinib for ALK-rearranged non-small cell lung cancer: a new targeted therapy for a new target.

@article{Gandhi2012CrizotinibFA,
  title={Crizotinib for ALK-rearranged non-small cell lung cancer: a new targeted therapy for a new target.},
  author={Leena Gandhi and Pasi Antero J{\"a}nne},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 14},
  pages={3737-42}
}
Crizotinib (PF02341066, Xalkori; Pfizer) was recently approved by the U.S. Food and Drug Administration for treatment of ALK-positive non-small cell lung cancer (NSCLC) as defined by a jointly approved diagnostic test using a break-apart fluorescence in situ hybridization assay. The approval was based on dramatic response rates in ALK-positive NSCLC patients of 54% to 61% in phase I and II trials. To date, the overall disease control rates in these trials are close to 90%. Progression-free… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Correlation of IHC and FISH for ALK gene rearrangement in non-small cell lung carcinoma: IHC score algorithm for FISH.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer • 2011
View 10 Excerpts
Highly Influenced

Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers.

Science translational medicine • 2012
View 6 Excerpts
Highly Influenced

Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2012
View 3 Excerpts

ROS1 rearrangements define a unique molecular class of lung cancers.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2012
View 2 Excerpts

CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2011
View 1 Excerpt

Similar Papers

Loading similar papers…