Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease.

@article{Ataga2017CrizanlizumabFT,
  title={Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease.},
  author={Kenneth I Ataga and Abdullah Kutlar and Julie Kanter and Darla K. Liles and Rodolfo Delfini Cançado and Jo{\~a}o Ricardo Friedrisch and Troy H. Guthrie and Jennifer M Knight-Madden and Ofelia A Alvarez and Victor R Gordeuk and Sandra F. M. Gualandro and Marina Pereira Colella and Wally R. Smith and Scott A Rollins and Jonathan Stocker and Russell P. Rother},
  journal={The New England journal of medicine},
  year={2017},
  volume={376 5},
  pages={
          429-439
        }
}
BACKGROUND The up-regulation of P-selectin in endothelial cells and platelets contributes to the cell-cell interactions that are involved in the pathogenesis of vaso-occlusion and sickle cell-related pain crises. The safety and efficacy of crizanlizumab, an antibody against the adhesion molecule P-selectin, were evaluated in patients with sickle cell disease. METHODS In this double-blind, randomized, placebo-controlled, phase 2 trial, we assigned patients to receive low-dose crizanlizumab (2… CONTINUE READING

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