Critiquing cryos.


Type II (mixed) cryoglobulin represents circulating immune complexes composed of a monoclonal IgM associated to a polyclonal IgG, which defines it as a rheumatoid factor.1 The cryoprecipitable immune complex can be found in the complete absence of clinical symptoms, but can deposit diffusely on endothelial surfaces, activate complement, and produce a… (More)
DOI: 10.1182/blood-2008-03-144030


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