Critically Ill Children Have Low Vitamin D-Binding Protein, Influencing Bioavailability of Vitamin D.

@article{Madden2015CriticallyIC,
  title={Critically Ill Children Have Low Vitamin D-Binding Protein, Influencing Bioavailability of Vitamin D.},
  author={Kate Madden and Henry A. Feldman and Rene F. Chun and Ellen M. Lavoie Smith and Ryan M Sullivan and Anna A. Agan and Shannon M Keisling and Angela Panoskaltsis-Mortari and Adrienne G Randolph},
  journal={Annals of the American Thoracic Society},
  year={2015},
  volume={12 11},
  pages={
          1654-61
        }
}
RATIONALE Vitamin D deficiency, often defined by total serum 25-hydroxyvitamin D (25[OH]D) <20 ng/ml, is common in critically ill patients, with associations with increased mortality and morbidity in the intensive care unit. Correction of vitamin D deficiency in critical illness has been recommended, and ongoing clinical trials are investigating the effect of repletion on patient outcome. The biologically active amount of 25(OH)D depends on the concentration and protein isoform of vitamin D… CONTINUE READING
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