Critical time window of neuronal cholesterol synthesis during neurite outgrowth.


Cholesterol is an essential membrane component enriched in plasma membranes, growth cones, and synapses. The brain normally synthesizes all cholesterol locally, but the contribution of individual cell types to brain cholesterol metabolism is unknown. To investigate whether cortical projection neurons in vivo essentially require cholesterol biosynthesis and… (More)
DOI: 10.1523/JNEUROSCI.1352-11.2012


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