Critical sulfhydryls regulate calcium release from sarcoplasmic reticulum.

  title={Critical sulfhydryls regulate calcium release from sarcoplasmic reticulum.},
  author={Jonathan J. Abramson and Guy Salama},
  journal={Journal of bioenergetics and biomembranes},
  volume={21 2},
Rapid Ca2+ release from the sarcoplasmic reticulum (SR)3 can be triggered by either binding of heavy metals to a sulfhydryl (SH) group or by catalyzing the oxidation of endogenous groups to a disulfide. Ca2+ release has been monitored directly using isolated vesicle preparations or indirectly by monitoring phasic contractions in a skinned fiber preparation. SH oxidation triggered by addition of Cu2+/mercaptans, phthalocyanine dyes, reactive disulfides, and various anthraquinones appears to… CONTINUE READING

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