Critical salt bridges guide capsid assembly, stability, and maturation behavior in bacteriophage HK97.

@article{Gertsman2010CriticalSB,
  title={Critical salt bridges guide capsid assembly, stability, and maturation behavior in bacteriophage HK97.},
  author={Ilya Gertsman and Chi-yu Fu and Rick Huang and Elizabeth A. Komives and John E. Johnson},
  journal={Molecular & cellular proteomics : MCP},
  year={2010},
  volume={9 8},
  pages={1752-63}
}
HK97 is a double-stranded DNA bacteriophage that undergoes dramatic conformational changes during viral capsid maturation and for which x-ray structures, at near atomic resolution, of multiple intermediate and mature capsid states are available. Both amide H/(2)H exchange and crystallographic comparisons between the pre-expanded Prohead II particles and the expanded Head II of bacteriophage HK97 revealed quaternary interactions that remain fixed throughout maturation and appear to maintain… CONTINUE READING

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