Critical roles of interferon regulatory factor 4 in CD11bhighCD8alpha- dendritic cell development.

Abstract

IFN regulatory factors (IRFs) are a family of transcription factors that play an essential role in the homeostasis and function of immune systems. Recent studies indicated that IRF-8 is critical for the development of CD11b(low)CD8alpha(+) conventional dendritic cells (DCs) and plasmacytoid DCs. Here we show that IRF-4 is important for CD11b(high)CD8alpha(-) conventional DCs. The development of CD11b(high) DCs from bone marrow of IRF-4(-/-) mice was severely impaired in two culture systems supplemented with either GM-CSF or Flt3-ligand. In the IRF-4(-/-) spleen, the number of CD4(+)CD8alpha(-) DCs, a major subset of CD11b(high) DCs, was severely reduced. IRF-4 and IRF-8 were expressed in the majority of CD11b(high)CD4(+)CD8alpha(-) DCs and CD11b(low)CD8alpha(+) DCs, respectively, in a mutually exclusive manner. These results imply that IRF-4 and IRF-8 selectively play critical roles in the development of the DC subsets that express them.

DOI: 10.1073/pnas.0402139101
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@article{Suzuki2004CriticalRO, title={Critical roles of interferon regulatory factor 4 in CD11bhighCD8alpha- dendritic cell development.}, author={Shoichi Suzuki and Kiri Honma and Toshifumi Matsuyama and Kazuo Suzuki and Kan Toriyama and Ichinose Akitoyo and Kazuo Yamamoto and Takashi Suematsu and Michio Nakamura and Katsuyuki Yui and Atsushi Kumatori}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2004}, volume={101 24}, pages={8981-6} }