Critical roles of glycosaminoglycan side chains of cartilage proteoglycan (aggrecan) in antigen recognition and presentation.

@article{Glant1998CriticalRO,
  title={Critical roles of glycosaminoglycan side chains of cartilage proteoglycan (aggrecan) in antigen recognition and presentation.},
  author={Tibor T. Glant and Edit Ir{\'e}n Buz{\'a}s and A Finnegan and Gabriela Negroiu and Gabriella Cs-Szab{\'o} and Katalin Mikecz},
  journal={Journal of immunology},
  year={1998},
  volume={160 8},
  pages={3812-9}
}
Systemic immunization of BALB/c mice with proteoglycan (aggrecan) from fetal human cartilage induces progressive polyarthritis, an experimental disease similar to human rheumatoid arthritis. The development of the disease in this genetically susceptible murine strain is based on cross-reactive immune responses between the immunizing fetal human and mouse self-proteoglycans. One of the cross-reactive and arthritogenic T cell epitopes (92GR/QVRVNSA/IY) is localized in the G1 domain of human… CONTINUE READING