Critical roles of coactivator p300 in mouse embryonic stem cell differentiation and Nanog expression.

@article{Zhong2009CriticalRO,
  title={Critical roles of coactivator p300 in mouse embryonic stem cell differentiation and Nanog expression.},
  author={Xiaomin Zhong and Ying Jin},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 14},
  pages={9168-75}
}
p300 is a well known histone acetyltransferase and coactivator that plays pivotal roles in many physiological processes. Despite extensive research for the functions of p300 in embryogenesis and transcription regulation, its roles in regulating embryonic stem (ES) cell pluripotency are poorly understood. To address this issue, we investigated the self-renewal ability and early differentiation process in both wild-type mouse ES cells and ES cells derived from p300 knock-out (p300(-/-)) mice. We… CONTINUE READING

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