Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora.

@article{Fagarasan2002CriticalRO,
  title={Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora.},
  author={Sidonia Fagarasan and Masamichi Muramatsu and Keiichiro Suzuki and Hitoshi Nagaoka and Hiroshi Hiai and T. Honjo},
  journal={Science},
  year={2002},
  volume={298 5597},
  pages={1424-7}
}
Activation-induced cytidine deaminase (AID) plays an essential role in class switch recombination (CSR) and somatic hypermutation (SHM) of immunoglobulin genes. We report here that deficiency in AID results in the development of hyperplasia of isolated lymphoid follicles (ILFs) associated with a 100-fold expansion of anaerobic flora in the small intestine. Reduction of bacterial flora by antibiotic treatment of AID-/- mice abolished ILF hyperplasia as well as the germinal center enlargement… CONTINUE READING
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