Critical roles of a small conductance Ca²⁺-activated K⁺ channel (SK3) in the repolarization process of atrial myocytes.

@article{Zhang2014CriticalRO,
  title={Critical roles of a small conductance Ca²⁺-activated K⁺ channel (SK3) in the repolarization process of atrial myocytes.},
  author={Xiaodong Zhang and Valeriy Timofeyev and Ning Li and Richard E Myers and Dai-Min Zhang and Anil Singapuri and Victor C Lau and Chris T. Bond and John P Adelman and Deborah K Lieu and Nipavan Chiamvimonvat},
  journal={Cardiovascular research},
  year={2014},
  volume={101 2},
  pages={317-25}
}
AIMS Small conductance Ca(2+)-activated K(+) channels (K(Ca)2 or SK channels) have been reported in excitable cells, where they aid in integrating changes in intracellular Ca(2+) (Ca(i)²⁺) with membrane potentials. We have recently reported the functional expression of SK channels in human and mouse cardiac myocytes. Additionally, we have found that the channel is highly expressed in atria compared with the ventricular myocytes. We demonstrated that human cardiac myocytes expressed all three… CONTINUE READING
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