Critical roles for polymerase zeta in cellular tolerance to nitric oxide-induced DNA damage.

@article{Wu2006CriticalRF,
  title={Critical roles for polymerase zeta in cellular tolerance to nitric oxide-induced DNA damage.},
  author={Xiaohua Wu and Katsuya Takenaka and Eiichiro Sonoda and Helfrid Hochegger and Shosuke Kawanishi and Takuo Kawamoto and Shunichi Takeda and Mitsuyoshi Yamazoe},
  journal={Cancer research},
  year={2006},
  volume={66 2},
  pages={748-54}
}
Nitric oxide (NO), a signal transmitter involved in inflammation and regulation of smooth muscle and neurons, seems to cause mutagenesis, but its mechanisms have remained elusive. To gain an insight into NO-induced genotoxicity, we analyzed the effect of NO on a panel of chicken DT40 clones deficient in DNA repair pathways, including base and nucleotide excision repair, double-strand break repair, and translesion DNA synthesis (TLS). Our results show that cells deficient in Rev1 and Rev3, a… CONTINUE READING