Critical roles for both STAT1-dependent and STAT1-independent pathways in the control of primary dengue virus infection in mice.

@article{Shresta2005CriticalRF,
  title={Critical roles for both STAT1-dependent and STAT1-independent pathways in the control of primary dengue virus infection in mice.},
  author={Sujan Shresta and Kristin L. Sharar and Daniil M. Prigozhin and Heidi M. Snider and P. Robert Beatty and Eva Harris},
  journal={Journal of immunology},
  year={2005},
  volume={175 6},
  pages={3946-54}
}
Dengue virus (DEN), a flavivirus, causes dengue fever and dengue hemorrhagic fever/dengue shock syndrome, the most common mosquito-borne viral illnesses in humans worldwide. In this study, using STAT1(-/-) mice bearing two different mutant stat1 alleles in the 129/Sv/Ev background, we demonstrate that IFNR-dependent control of primary DEN infection involves both STAT1-dependent and STAT1-independent mechanisms. The STAT1 pathway is necessary for clearing the initial viral load, whereas the… CONTINUE READING
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