Critical role of vascular endothelial growth factor secreted by mesenchymal stem cells in hyperoxic lung injury.

@article{Chang2014CriticalRO,
  title={Critical role of vascular endothelial growth factor secreted by mesenchymal stem cells in hyperoxic lung injury.},
  author={Yun Sil Chang and So Yoon Ahn and Hong Bae Jeon and Dong Kyung Sung and Eun Sun Kim and Se In Sung and Hye Soo Yoo and Soo Jin Choi and Won Il Oh and Won Soon Park},
  journal={American journal of respiratory cell and molecular biology},
  year={2014},
  volume={51 3},
  pages={
          391-9
        }
}
Intratracheal transplantation of human umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) protects against neonatal hyperoxic lung injury by a paracrine rather than a regenerative mechanism. However, the role of paracrine factors produced by the MSCs, such as vascular endothelial growth factor (VEGF), has not been delineated. This study examined whether VEGF secreted by MSCs plays a pivotal role in protecting against neonatal hyperoxic lung injury. VEGF was knocked down in human… CONTINUE READING
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