Critical role of transglutaminase and other stress proteins during neurodegenerative processes

  title={Critical role of transglutaminase and other stress proteins during neurodegenerative processes},
  author={D. Caccamo and M. Curr{\`o} and S. Condello and N. Ferlazzo and R. Ientile},
  journal={Amino Acids},
  • D. Caccamo, M. Currò, +2 authors R. Ientile
  • Published 2009
  • Biology, Medicine
  • Amino Acids
  • Proteolytic stress, resulting from the intracellular accumulation of misfolded or aggregated proteins, which exceed the capacity of the ubiquitin–proteasome system to degrade them, plays a relevant role in neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s chorea. Most of toxic protein aggregates are characterised by the presence of isopeptide bonds (cross-links) catalysed by transglutaminase activity; further, several disease-specific proteins—tau… CONTINUE READING
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