Critical role of the transient activation of p38 MAPK in the etiology of skeletal muscle insulin resistance induced by low-level in vitro oxidant stress.

@article{DiamondStanic2011CriticalRO,
  title={Critical role of the transient activation of p38 MAPK in the etiology of skeletal muscle insulin resistance induced by low-level in vitro oxidant stress.},
  author={M. Diamond-Stanic and Elizabeth M Marchionne and M. K. Teachey and David E Durazo and J. Kim and E. Henriksen},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={405 3},
  pages={
          439-44
        }
}
  • M. Diamond-Stanic, Elizabeth M Marchionne, +3 authors E. Henriksen
  • Published 2011
  • Biology, Medicine
  • Biochemical and biophysical research communications
  • Increased cellular exposure to oxidants may contribute to the development of insulin resistance and type 2 diabetes. Skeletal muscle is the primary site of insulin-dependent glucose disposal in the body; however, the effects of oxidative stress on insulin signaling and glucose transport activity in mammalian skeletal muscle are not well understood. We therefore studied the effects of a low-level in vitro oxidant stress (30-40 μM H2O2) on basal and insulin-stimulated (5 mU/ml) glucose transport… CONTINUE READING
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