Critical role of the rostral ventromedial medulla in early spinal events leading to chronic constriction injury neuropathy in rats.

@article{Sanoja2008CriticalRO,
  title={Critical role of the rostral ventromedial medulla in early spinal events leading to chronic constriction injury neuropathy in rats.},
  author={Raul Sanoja and Horacio Vanegas and V{\'i}ctor Tortorici},
  journal={The journal of pain : official journal of the American Pain Society},
  year={2008},
  volume={9 6},
  pages={532-42}
}
UNLABELLED Neuropathic pain is a major clinical problem, and several animal models have been developed to investigate its mechanisms and its treatment. In this report, the role of the rostral ventromedial medulla (RVM) in the early events of the chronic constriction injury (CCI) model was investigated in behavioral and electrophysiological experiments. Placing the 4 CCI ligatures around the sciatic nerve induced large discharges and residual ongoing activity in spinal nociceptive neurons. Two… CONTINUE READING