Critical role of the HMGI(Y) proteins in adipocytic cell growth and differentiation.

  title={Critical role of the HMGI(Y) proteins in adipocytic cell growth and differentiation.},
  author={Rosa Marina Melillo and Giovanna Maria Pierantoni and Stefania Scala and Sarah Battista and Monica Fedele and Alexandre Stella and Maria Cristina De Biasio and Gennaro Chiappetta and Vincenzo Fidanza and Gianluigi Condorelli and Massimo Santoro and Carlo M. Croce and Giuseppe Viglietto and Alfredo Fusco},
  journal={Molecular and cellular biology},
  volume={21 7},
The high-mobility group I (HMGI) nonhistone chromosomal proteins HMGI(Y) and HMGI-C have been implicated in defining chromatin structure and in regulating the transcription of several genes. These proteins have been implicated in adipocyte homeostasis: a severe deficiency of fat tissue is found in mice with targeted disruption of the HMGI-C locus, and lipomagenesis in humans is frequently associated with somatic mutations of HMGI genes. The aim of this study was to examine the role of HMGI(Y… CONTINUE READING
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