Critical role of the FERM domain in Pyk2 stimulated glioma cell migration.

@article{Lipinski2006CriticalRO,
  title={Critical role of the FERM domain in Pyk2 stimulated glioma cell migration.},
  author={Christopher A. Lipinski and Nhan L. Tran and Andrea G Dooley and Yuan-Ping Pang and Carole Rohl and Jean Kloss and Zhongbo Yang and Wendy S. McDonough and David Craig and Michael E. Berens and Joseph C. Loftus},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={349 3},
  pages={939-47}
}
The strong tendency of malignant glioma cells to invade locally into surrounding normal brain precludes effective surgical resection, reduces the efficacy of radiotherapy, and is associated with increased resistance to chemotherapy regimens. We report that the N-terminal FERM domain of Pyk2 regulates its promigratory function. A 3-dimensional model of the Pyk2 FERM domain was generated and mutagenesis studies identified residues essential for Pyk2 promigratory function. Model-based targeted… CONTINUE READING

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