Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance.

@article{GutirrezJurez2006CriticalRO,
  title={Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance.},
  author={Roger Guti{\'e}rrez-Ju{\'a}rez and Alessandro Pocai and Claudia Mulas and Hiraku Ono and Sanjay Bhanot and Brett P. Monia and Luciano Rossetti},
  journal={The Journal of clinical investigation},
  year={2006},
  volume={116 6},
  pages={1686-95}
}
Stearoyl-CoA desaturase-1 (SCD1) catalyzes the synthesis of monounsaturated fatty acids from saturated fatty acids. Mice with a targeted disruption of Scd1 gene locus are lean and display increased insulin sensitivity. To examine whether Scd1 activity is required for the development of diet-induced hepatic insulin resistance, we used a sequence-specific antisense oligodeoxynucleotide (ASO) to lower hepatic Scd1 expression in rats and mice with diet-induced insulin resistance. Treatment of rats… CONTINUE READING
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