Critical role of reactive oxygen species formation in microcystin-induced cytoskeleton disruption in primary cultured hepatocytes.

@article{Ding2001CriticalRO,
  title={Critical role of reactive oxygen species formation in microcystin-induced cytoskeleton disruption in primary cultured hepatocytes.},
  author={W. X. Ding and H M Shen and Choon Nam Ong},
  journal={Journal of toxicology and environmental health. Part A},
  year={2001},
  volume={64 6},
  pages={507-19}
}
Cyanobacteria (blue-green algae)-contaminated water is a worldwide public health problem. Microcystins are a group of liver-specific toxins generated by cyanobacteria. It is generally believed that the protein phosphorylation that leads to the disruption of intermediate filaments plays an important role in microcystin-induced hepatotoxicity. However, the mechanisms that contribute to the microcystin-induced alterations of microtubules and microfilaments are not fully understood. In the present… CONTINUE READING

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