Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induced rapid apoptosis in rat hepatocytes.

Abstract

Microcystin-LR (M-LR) is a specific hepatotoxin. At present, the exact toxic mechanism of its action remains unclear though apoptosis is believed to be involved. This study was designed to investigate the role of reactive oxygen species (ROS) and mitochondrial permeability transition (MPT) in the M-LR-induced apoptotic process. Morphologic changes such as… (More)

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Cite this paper

@article{Ding2000CriticalRO, title={Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induced rapid apoptosis in rat hepatocytes.}, author={W. X. Ding and H. M. Shen and Cynthia Ong}, journal={Hepatology}, year={2000}, volume={32 3}, pages={547-55} }